Estrogen Metabolism Assessment

Estrogen is a very powerful hormone said to react in a “paradoxical fashion.” It is metabolized in two ways:

1) Estrogen is converted into a metabolite called 16alpha-hydroxyestrone (16alpha-OHE1), which stimulates target tissues. Levels of this metabolite can rise in response to obesity, alcohol consumption, and toxic exposure. High levels of 16alph-OHE1 are associated with increased risk and poorer prognosis in conditions associated with estrogen excess, such as breast cancer and lupus.

2) Estrogen is also converted into a less powerful metabolite called 2-hydroxyestrone (2-OHE1). This metabolite binds to cell receptors and can
slow cell production. Excess levels of 2-OHE1 can lead to conditions associated with estrogen deficiency, such as heart disease, depression, and

A New Leaf’s Meridian Valley Laboratories Estrogen Metabolism Assessment evaluates how estrogen is being used in the body and assesses the 16alpha-OHE1/2-OHEI balance. A proper balance of these two metabolites is imperative for women’s hormonal health. This test allows doctors to design individualized therapies based on each woman’s unique health needs, perhaps by integrating lignans (flaxseeds), isoflavons (soy products), and indole-3-carbinol (cruciferous vegetables) into the diet, supplementing with omega-3 fatty acids, and increasing patients’ daily exercise level. The Estrogen Metabolism Assessment is useful for both pre and postmenopausal women.